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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant protein within human LRP6 aa 100-300 / 1613.
- 亚型:
IgG2b
- 形态:
Liquid
- 克隆性:
Mouse monoclonal Antibody
- 标记物:
Non-conjugated
- 适应物种:
Human
- 库存:
现货
- 供应商:
华安生物
- 宿主:
Mouse
- 应用范围:
WB,IHC-P
- 浓度:
2 mg/mL.
- 规格:
50ul/100ul
| 规格: | 50ul | 产品价格: | ¥1125.0 |
|---|---|---|---|
| 规格: | 100ul | 产品价格: | ¥1875.0 |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
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文献和实验相关实验
v468.chapter 1 经典 Wnt/b-Catenin 信号通路 (英文完整版)
or LRP6 triggers the formation of Dishevelled (Dvl)/Frizzled (Fzd) complexes. The resulting generationof LRP/Fzd/Dsh aggregates at the cell membrane induces the phosphorylation of LRP by CK1a, thereby facilitating relocationof Axin to the membrane
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LRP6
¥1125 - 1875







