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Ubiquitin-like modifier-activa

ting enzyme 1
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  • ¥1125 - 1875
  • HuaBio/华安生物
  • 华安生物
  • ET1612-82
  • 2025年07月13日
  • WB, ICC/IF, IHC-P, FC
  • Rabbit
  • Human, Mouse
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide within Human UBA1 aa 1,009-1,058 / 1,058.

    • 亚型

      IgG

    • 形态

      Liquid

    • 克隆性

      Recombinant Rabbit monoclonal Antibody

    • 标记物

      Non-conjugated

    • 适应物种

      Human, Mouse

    • 库存

      现货

    • 供应商

      华安生物

    • 宿主

      Rabbit

    • 应用范围

      WB, ICC/IF, IHC-P, FC

    • 浓度

      1 mg/mL.

    • 规格

      50μl/100μl

    规格:50μl产品价格:¥1125.0
    规格:100μl产品价格:¥1875.0
    The ubiquitin activating enzyme E1 (UBE1) catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. Specifically, UBE1 functions to adenylate the C-terminal glycine residue of ubiquitin, a reaction that is ATP-dependent and is proceeded by the formation of a thiolester bond with a cysteine residue of UBE1. The UBE1-activated ubiquitin is then transferred to a ubiquitin conjugated enzyme, which donates the ubiquitin residue to target substrates. The UBE1 gene is an example of an X-Y homologous gene, which is X-linked with a distinct Y-linked gene in many mammals. However, no UBE1 homolog is detectable on the human Y chromosome. UBE1 is thought to escape X inactivation in humans.

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    图标文献和实验
    相关实验
    • Studies of the Ubiquitin Proteasome System

      and Purification of Anti‐Ubiquitin Antibodies Support Protocol 3: Preparation of Ubiquitin Affinity Column Generation of Reagent‐Grade Ubiquitin Activating Enzyme (E1) Basic Protocol 20: Preparation of Wheat E1 in E. coli Basic Protocol 21: Preparation of Mouse E1

    • Assays for RING Family Ubiquitin Ligases

      through an enzymatic cascade of three discrete steps, which results in covalent attachment of ubiquitin to the substrate. The first two steps in this cascade involve the activating and conjugating enzymes, E1 and E2. The third and final step is performed by the E3

    • CDK-Activating Kinases: Detection and Activity Measurements

      All cyclin-dependent kinases (CDKs) involved in eukaryotic cell cycle control require phosphorylation at a conserved threonine (or serine) residue within the activation- or T-loop to attain full enzymatic activity. The enzyme responsible

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