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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1246812-22-5
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥2160.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥5490.0 |
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Ramelteon metabolite M-II-d3
CAS No. : 1246812-22-5
MCE 国际站：Ramelteon metabolite M-II-d3
产品活性：Ramelteon metabolite M-II-d3 是 Ramelteon metabolite M-II 的氘代物。Ramelteon metabolite M-II 是雷美替胺 (Ramelteon) 的主要代谢物，其对人褪黑素受体 1 和 2 的 IC50 值分别为 208 pM 和 1470 pM。雷美替胺是褪黑素受体 (melatonin) 的选择性激动剂。
研究领域：GPCR/G Protein | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点：Melatonin Receptor | Drug Metabolite
In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
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文献和实验Characterization of Angiotensin II Receptors
Figure 1.10.3 The inhibition of [125 I]Ang II binding in intact Chinese hamster ovary cells expressing AT1A receptors. The IC50 values are 2.3 nM (Ang II), 22 nM (losartan), >1 µM (PD123177), 1.7 nM
for their technical assistance. REFERENCES [1]Traut, T.W. Physiological concentrations of purines and pyrimidines. Mol.Cell. Biochem. 140 (1994) 1-22 [2]Carlucci, F., Rosi, F., Di Pietro, C., Marinello, E., Pizzichini, M. and Tabucchi, A. Purine nucleotide
21 Li FS, Barnathan ES, Kariko K. Rapid method for screening and cloning cDNA generated in differential mRNA display: application of northern blot for affinity capturing of cDNAs. Nucleic Acids Res, 1994，22（9)∶1764～1765 22 Hubank M, Schatz DG
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