Recombinant fusion protein containing a sequence corresponding to amino acids 22-319 of human CD68
Calculated molecular weight
31kDa/34kDa/37kDa
Observed molecular weight
85kDa
Swiss Prot
P34810
Gene ID (NCBI)
968
Alternative Names
CD68; GP110; LAMP4; SCARD1; macrosialin
Application Notes:
WB
1:500 - 1:2000
IHC
1:50 - 1:200
Western blot analysis of extracts of various cell lines, using CD68 antibody.
Immunohistochemistry of paraffin-embedded rat spleen using CD68 antibody.
Immunohistochemistry of paraffin-embedded mouse spleen using CD68 antibody.
Immunohistochemistry of paraffin-embedded mouse thymus using CD68 antibody.
Background:
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Storage:
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.