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文献和实验Assays for Cyclin-Dependent Kinase Inhibitors
of the Retinoblastoma gene product (Rb) by CDK4 and/or CDK6 (G1/S checkpoint), leading to the release of bound E2F from Rb and allowing the transcription of genes by “free E2F” necessary for S phase progression. During late G1 phase, CDK2/cyclin E complex phosphorylates
Analysis of Cyclin-Dependent Kinase Activity
of the cell cycle that require their kinase abilities—CDKs 3, 4, and 6 are active during G1 phase, CDK2 functions during the G1-to-S transition and S phase, and cdc2 (also known as cdk1) is essential for the G2-to-mitosis transition ( 3 ). In vivo
a look from the following website just by clicking "Tyrosine Phosphorylation and Dimerization" http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-43F85YV-2&_user=1111158&_coverDate=06%2F29%2F2001&_rdoc=1&_fmt=full&_orig=search
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