NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).{27789,25556} It can also activate voltage-gated Kv11
库存:
10 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
18711-16-5
A nonselective activator of SK/KCa2 and IK/KCa3.1 channels (EC50s range from 0.12-1.2 µM and 10-90 nM for SK and IK channels, respectively); also activates Kv11.1 channels (hERG; IC50 = 1 µM), but does not affect BK/KCa1.1 channels; modulates neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects