(±)-trans-ACPD is an agonist of metabotropic glutamate receptors (mGluRs; EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors).{47711} It also activates mGluR4 in baby hamster kidn
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
67684-64-4
An agonist of mGluRs (EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors, and ~800 µM for mGluR4 in baby hamster kidney cells); increases cAMP accumulation in adult rat cerebral cortex slices (EC50 = 47.8 µM) but not in isolated rat embryonic neurons or neonatal glial cells at 1-1,000 µM; increases phosphoinositide hydrolysis in neonatal rat cerebral cortex and hippocampal slices at 10-1,000 µM; induces convulsions in neonatal rats (ED50 = 100 mg/kg), an effect that can be reversed by administration of the NMDA receptor antagonists LY233053 and LY274614