ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells wi
库存:
1 mg, 10 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
1197958-12-5
规格:
This biochemical is available in the following size(s) 10 mg, 25 mg, 5 mg - Please inquire
A potent inhibitor of ALK (IC50 = 0.07 nM) that is less effective at IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively); drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM