Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage sensor and activates the DNA repair enzyme ataxia-telangiectasia mutated kinase (ATM).{16934} It inhibits phosphorylation of H2AX induced by DNA containing dsDN
库存:
10 mg, 100 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
299953-00-7
A MRN complex inhibitor; inhibits DSB-induced H2AX phosphorylation (IC50 = 66 µM in X. laevis cell-free extracts); inhibits the exonuclease activity of Mre11 in a cell-free assay at 100 µM; induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner; reduces tumor growth in an LA-N-5 mouse xenograft model when encapsulated in nanoparticles at 50 mg/kg