AEG 3482 is an inhibitor of p75NTR- and NRAGE-induced apoptosis.{49017} It inhibits JNK signaling, caspase-3 cleavage, and cell death induced by the p75 neurotrophin receptor (p75NTR) or the p75NTR-interacting protein NRAGE in PC12rtTA cells in a concen
库存:
1 mg, 10 mg, 25 mg, 5 mg
供应商:
Cayman
CAS号:
63735-71-7
An inhibitor of p75NTR- and NRAGE-induced apoptosis; inhibits JNK signaling, caspase-3 cleavage, and cell death induced by p75NTR or NRAGE in PC12rtTA cells in a concentration-dependent manner; inhibits cell death induced by withdrawal of NGF in rat SCG neurons (EC50 = ~20 μM); increases Hsp70 and Hsp25 levels in MEFs in an HSF1-dependent manner; binds recombinant Hsp90