The transmembrane enzyme KIAA1363 (also known as AADACL1) controls the production of the monoalkylglycerol ether (MAGE) class of neutral ether lipids (NELs) in cancer cells.{14603} Hyperactivity of this 2-acetyl MAGE hydrolase is associated with tumor ce
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
1354359-53-7
A potent, selective inhibitor of KIAA1361 (IC50s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes); reduces PC3 tumor xenograft growth in immune-deficient SCID mice at an oral dose of 80 mg/kg