The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors.{24819} They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRα and LX
库存:
1 mg, 10 mg, 5 mg
供应商:
Cayman
CAS号:
1416153-62-2
A liver-specific inverse agonist of the two LXR isoforms, LXRα and LXRβ (IC50s = 214 and 43 nM, respectively); suppresses hepatic lipogenesis, inflammation, lipid accumulation, and fibrosis in mouse models of non-alcoholic steatohepatitis