Ibotenic acid (60573-88-8) is a conformationally restricted analog of glutamate which occurs naturally in Amanita mascaria and related mushrooms. It is a non-specific glutamate receptor (both NMDA and mGluR) agonist.1 May be used to induce hippocampal lesioning in rat neurodegeneration models.2,3 Induces lesions in the subiculum in a mouse model of Alzheimer’s disease.4 Ibotenic acid(60573-88-8)是谷氨酸的构象限制性类似物,自然存在于毒鹅膏菌和相关蘑菇中。 它是一种非特异性谷氨酸受体(NMDA和mGluR)激动剂 可用于大鼠神经退行性变模型的海马损伤。 2,3诱导阿尔茨海默病小鼠模型的下丘脑病变。
References/Citations:
1) Nakanishi (1992), Molecular diversity of glutamate receptors and implications for brain function; Science 258 597 2) Jarrard (1989), On the use of ibotenic acid to lesion selectively different components of the hippocampal formation; J. Neurosci. Methods 29 251 3) Isacson and Peschanski (1992), Is there capacity for anatomical and functional repair in the adult somatosensory thalamus?; Exp. Neurol. 115 173 4) George et al. (2014), Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease; Acta Neuropathol. Commun. 2 17
CAS:
2552-55-8
Catalog Number:
10-2693
Activity:
NMDA and mGluR agonist
Chemical Name:
α-Amino-3-hydroxy-5-isoxazoleacetic acid hydrate
Molecular Weight:
176.13
Molecular Formula:
C5H6N2O4 • H2O
Solubility:
Soluble in Water (up to 1 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
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