Citalopram HBr (59729-32-7) is a potent and selective serotonin uptake inhibitor (SSRI) Ki=5.4 nM. Has no effect on norepinephrine or dopamine uptake.1 Displays cardioprotective effects in part by reducing expression of cytokine-induced endothelial adhesion molecules, ICAM-1 and VCAM-1.2 Clinically useful antidepressant.3 Attenuates ethanol intake.4 西酞普兰HBr(59729-32-7)是一种有效的选择性血清素吸收抑制剂(SSRI) Ki=5.4 nM。 对去甲jiashangxian和多巴胺的摄入没有影响 显示心脏保护作用部分是通过降低细胞因子诱导的内皮粘附分子ICAM-1和VCAM-1.2的表达 减弱乙醇摄入。
References/Citations:
1) Mateo et al. (2000), Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo; Neuropharmacology 39 2036 2) Lekakis et al. (2010), Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules; Int. J. Cardiol. 139 150 3) Cipriani et al. (2009), Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis; Lancet 373 746 4) Naranjo et al. (1987), The serotonin uptake inhibitor citalopram attenuates ethanol intake; Clin. Pharmacol. Ther. 41 266
CAS:
59729-32-7
Catalog Number:
10-2458
Activity:
Serotonin uptake inhibitor
Chemical Name:
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
Molecular Weight:
405.31
Molecular Formula:
C20H21FN2O HBr
Solubility:
Soluble in Water (up to 4 mg/ml), DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water, DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT