DMXAA (117570-53-3) is a STING (Stimulator of Interferon Genes) agonist selective for mouse STING.1,2 Intratumoral administration of DMXAA resulted in tumor regression and complete rejection in mouse xenografts.3 Tumor regression induced by DMXAA results from a cascade of cellular events which include disruption of tumor vasculature followed by the release of chemokines which trigger the recruitment of immune cells.4 DMXAA induced expression of IFN-β resulting in a striking expansion of leukemia-specific T cells extending survival in two acute myeloid leukemia models.5 STING激动剂DMXAA(117570-53-3)是一种STING(干扰素基因刺激剂)激动剂,可选择性用于小鼠STING。瘤内给药DMXAA可导致小鼠异种移植瘤的肿瘤消退和完全排斥 DMXAA诱导的肿瘤消退是由一系列细胞事件引起的,其中包括肿瘤血管系统的破坏,随后释放的趋化因子触发免疫细胞的招募 DMXAA诱导IFN-β的表达,导致白血病特异性T细胞显著扩增,延长两种急性髓系白血病模型的生存时间。
References/Citations:
1) Prantner et al. (2012), 5,6-Dimethylzanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential; J. Biol. Chem., 287 39776 2) Conlon et al. (2013), Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid; J. Immunol., 190 5216 3) Corrales et al. (2015), Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and immunity; Cell Rep., 11 1018 4) Weiss et al. (2017), The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression; Oncoimmunology, 6 e1346765 5) Curran et al. (2016), STING Pathway Activation Stimulates Potent Immunity Against Acute Myeloid Leukemia; Cell Rep., 15 2357
CAS:
117570-53-3
Catalog Number:
10-2676
Activity:
STING agonist
Chemical Name:
5,6-Dimethylxanthenone-4-acetic acid
Alternate Names:
ASA404; Vadimezan
Molecular Weight:
282.29
Molecular Formula:
C17H14O4 Solubility:
Soluble in DMSO (up to 5 mg/ml) or in DMF (up to 14 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT
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