Orlistat (96829-58-2) is a lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α.1 Inhibits pancreatic lipase and other lipases but not PLA2.2 Inhibits fatty acid synthase and displays antitumor activity.3 Orlistat prevents fat absorption in the gut and is a clinically useful antiobesity agent.4 DAG脂肪酶-α抑制剂奥利司他(96829-58-2)是一种通过抑制DAG脂肪酶-α.1来阻断2-AG生物合成的脂肪酶抑制剂 2.抑制胰腺脂肪酶和其他脂肪酶,但不抑制pla2 .抑制脂肪酸合成酶,显示抗肿瘤活性 奥利司他可防止脂肪在肠道的吸收,是一种临床上有用的抗肥胖剂。
References/Citations:
1) Bisogno et al. (2006), Development of the first potent and specific inhibitors of endocannabinoid biosynthesis; Biochim. Biophys. Acta, 1761 205 2) Hadvary et al. (1991), The lipase inhibitor tetrahydrolipstatin bind covalently to the putative active site serine of pancreatic lipase; J. Biol. Chem., 266 2021 3) Kridel et al. (2004), Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity; Cancer Res., 64 2070 4) Ballinger and Peikin (2002), Orlistat: it’s current status as an anti-obesity drug; Eur. J. Pharmacol., 440 109
CAS:
96829-58-2
Catalog Number:
10-2448
Activity:
DAG Lipase-α inhibitor
Alternate Names:
Ro18-0647, (-)-Tetrahydrolipstatin
Chemical Name:
N-Formyl-L-leucine (1S)-10[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Molecular Weight:
495.75
Molecular Formula:
C29H53NO5 Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT
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