Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3 抗氧化剂trolox(53188-07-1)是维生素e的水溶性衍生物,具有抗氧化和清除自由基的活性 1 .防止hepg2细胞中CYP2E1诱导的脂质过氧化 2 . Trolox对过氧亚硝酸盐介导的大鼠胸腺细胞氧化应激和细胞凋亡的抑制作用 。
References/Citations:
1) Massey et al. (1990), Free radical damage in neonatal rat cardiac myocyte cultures: effects of alpha-tocopherol, Trolox and phytol; Free Radic. Biol. Med., 8 449 2) Chen et al. (1998), Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells; Mol. Pharmacol., 53 638 3) Brookes et al. (1996), Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes; Arch. Biochem. Biophys., 333 482
CAS:
53188-07-1
Catalog Number:
10-2393
Activity:
Antioxidant
Chemical Name:
6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Molecular Weight:
250.3
Molecular Formula:
C14H18O4 Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH.
Physical Properties:
Off-white solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
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