U0126 (109511-58-2) is a highly selective inhibitor of MEK1 and MEK2 in vitro and in vivo. Unlike PD98059 (Cat.# 10-2159), which only inhibits the activation of MEK1 and MEK2, U0126 inhibits both the active and inactive forms of the MEK enzymes. Inhibition of MEK1 and MEK2 has been demonstrated to enhance the self renewal of stem cells. U0126(109511-58-2)是一种体外和体内高选择性MEK1和MEK2抑制剂。 不像PD98059(猫。 U0126只抑制MEK1和MEK2的激活,U0126同时抑制活性和非活性的MEK酶。 抑制MEK1和MEK2已被证明可以增强干细胞的自我更新。
References/Citations:
1) Favata et al. (1998), Identification of a novel inhibitor of mitogen activated protein kinase kinase; J. Biol. Chem., 273 8623 2) Miyoshi et al. (2012), Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo; Int. J. Oncol., 41 449 3) Pricola et al. (2009), Interleukin-6 Maintains Bone Marrow-Derived Mesenchymal Stem Cell Stemness by an ERK1/2-Dependent Mechanism; J. Cell Biochem., 108 577
CAS:
109511-58-2
Catalog Number:
10-2179
Activity:
Selective MEK1 and MEK2 inhibitor
Chemical Name:
1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Molecular Weight:
380.49
Molecular Formula:
C18H16N6S2 Solubility:
Soluble in DMSO (up to 200 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
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