Indirubin-3′-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM).1 Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM).1 Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells.2 Possesses antiangiogenic activity.3 Indirubin-3′-monoxime attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease.4 Cell permeable. Indirubin-3′-monoxime(160807-49-8)是一种有效的GSK-3β抑制剂(IC50=22 nM) 抑制CDK1 (IC50=180 nM)和CDK5 (IC50=100 nM) 1 在HBL-100细胞中显示抗有丝分裂特性,并在前期阻滞后诱导内复制 具有抗血管新生activity.3 在阿尔茨海默病小鼠模型中,靛鲁宾-3′-肟可减弱β-淀粉样蛋白相关的神经病理学 细胞的渗透。
References/Citations:
1) Leclerc et al. (2001), Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?; J. Biol. Chem., 276 251 2) Damiens et al. (2001), Anti-mitotic properties of indirubin-3′-monoximine, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest; Oncogene, 20 3786 3) Kim et al. (2011), Indirubin-3′-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis; J. Cell. Biochem., 112 1384 4) Ding et al. (2010), Indirubin-3′-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease; Neurobiol. Dis., 39 156
CAS:
160807-49-8
Catalog Number:
10-1488
Activity:
GSK-3β and CDK inhibitor
Alternate Names:
Indirubin-3’oxime
Chemical Name:
3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Molecular Weight:
277.29
Molecular Formula:
C16H11N3O2 Solubility:
Soluble in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
Dark red or brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT