Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2 Directs differentiation of human and mouse ESCs to pancreatic cells.3 May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4 Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5 Indolactam V(-)(90365-57-4)是一种作用于phorbol酯结合位点的PKC激活剂。 1,2引导人类和小鼠ESCs向胰腺细胞分化 可能与其他试剂一起被用于将人类iPS细胞分化为葡萄糖反应型胰岛素分泌子细胞 增加G蛋白信号转导2 (RGS2)的调节蛋白水平,这是一种调节GPCR信号转导的蛋白 。
References/Citations:
1) Fujiki et al. (1984), Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gan., 75 866 2) Heikkila and Ackerman (1989), (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun, 162 1207 3) Chen et al. (2009), A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol., 5 258 4) Thalava et al. (2011), Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther., 18 283 5) Raveh (2014), Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol., 86 406
CAS:
90365-57-4
Catalog Number:
10-2145
Activity:
PKC activator; Stem cell inducer
Chemical Name:
(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Alternate Names:
ILV
Molecular Weight:
000.00
Molecular Formula:
C17H23N3O2 Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
Waxy lyophilized solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
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