IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppressive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide release in vitro.1 Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo.2 IQ-1S(1421610-21-0)是JNK3的抑制剂,JNK3、JNK2和JNK1的Kd分别为87、360和390 nM。 显示抗炎和免疫抑制活性。 抑制lps诱导的促炎细胞因子和一氧化dan的体外释放 减轻胶原诱导的关节炎严重程度和抑制小鼠迟发性超敏反应 。
References/Citations:
1) Schepetkin et al. (2012), Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors; Mol. Pharmacol., 81 832 2) Schepetkin et al. (2015), Anti-Inflammatory effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1A, a Selective c-Jun N-Terminal Kinase Inhibitor; J. Pharmacol. Exp. Ther., 353 505
CAS:
1421610-21-0
Catalog Number:
10-1513
Activity:
JNK3 inhibitor
Chemical Name:
11H-Indeno[1,2-b]quinoxaline-11-one oxime, sodium salt
Molecular Weight:
269.23
Molecular Formula:
C15H8N3O • Na
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT