Pyocyanine (85-66-5), a redox-active phenazine produced by P. aeruginosa and other pathogens, is an electron receptor, which stimulates redox cycling in bacteria as well as in a variety of human cell lines. It enhances oxidative metabolism, which increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanine accelerates neutrophil apoptosis in vitro. Pyocyanine production by P. aeruginosa suppresses the acute inflammatory response by pathogen-driven acceleration of neutrophil apoptosis and associated reduction of local inflammation. 绿脓杆菌(pycyanine, 85-66-5)是铜绿假单胞菌(P. aeruginosa)等病原菌产生的氧化还原活性非那嗪,是一种电子受体,能刺激细菌以及多种人类细胞系中的氧化还原循环。 它能促进氧化代谢,通过NADPH的还原增加细胞内活性氧(ROS)的形成。 pycyanine可加速中性粒细胞体外凋亡。 铜绿假单胞菌(P. aeruginosa)产生的碧菁通过病原体驱动的中性粒细胞凋亡加速和相关的局部炎症反应减轻来抑制急性炎症反应。
References/Citations:
1) Rada and Leto (2013), Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas Aeruginosa airway infections; Trends Microbiol., 21 73 2) Reszka et al. (2012), Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite; Am. J. Physiol. Lung Cell Mol. Physiol., 302 L1044
CAS:
85-66-5
Catalog Number:
10-1507
Activity:
ROS generator
Alternate Names:
Pyocyanin, Sanasin, Sanazin
Chemical Name:
5-Methyl-1(5H)-phenazinone
Molecular Weight:
210.23
Molecular Formula:
C13H10N2O
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
Dark blue solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT