Phos-tag Affinity Electrophoresis for Protein Kinase Profiling
Protein kinase profiling can provide a basis for understanding the molecular origins of diseases and, potentially, for developing tools for therapeutic intervention. It is therefore very important to develop advanced experimental procedures for convenient and accurate dete ...
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G Proteins in the Etiology and Treatment of Mental Disorders
Given their ubiquitous and crucial role in the integration and amplification of signal transduction pathways, it is not surprising that anomalies in the expression and/or function of various G proteins has been implicated in a multitude of pathophysiological states: pseudohypopa ...
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Patch-Clamp Techniques: General Remarks
The patch-clamp technique, invented by Erwin Neher and Bert Sakmann in 1976, was originally designed to detect the activity of single-ion channel proteins in the cell membrane. The technique is now widely used in the field of ion channel research for many purposes, such as to monitor changes in the tot ...
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Monitoring Axonal and Somatodendritic Dopamine Release Using Fast-Scan Cyclic Voltammetry in Brain Slices
Brain dopamine pathways serve wide-ranging functions including the control of movement, reward, cognition, learning, and mood. Consequently, dysfunction of dopamine transmission has been implicated in clinical conditions such as Parkinson’s disease, schizophrenia, addi ...
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