生物标志物检测阻塞性睡眠呼吸暂停的诊断准确性

Diagnostic accuracy of biological markers for detecting obstructive sleep apnoea

作者信息Graziela De Luca Canto, Patricia Pauletto, Cristine M Stefani, Eliete Ns Guerra, Ana Carolina Pereira Nunes Pinto, Nelson Carvas Junior, Carlos Flores Mir, David Gozal, Virginia Fm Trevisani

PMID42765455

期刊Cochrane Database Syst Rev

发布时间2026-09-21

DOI10.1002/14651858.CD016281

来源查看原文

实验完整度

低

本文为Cochrane诊断性系统评价方案，未开展原始实验，无明确实验方法与验证结果。

摘要

This is a protocol for a Cochrane review (diagnostic). The objectives are as follows: To determine the accuracy of any type of biological marker found in blood, saliva, urine or breath condensation to detect obstructive sleep apnoea (OSA) in adults (> 18 years). Secondary objectives To identify the accuracy of individual biomarkers alone or in combination for detecting OSA. To find the accuracy of biological markers compared to overnight polysomnography (PSG) and home sleep apnoea test (HSAT). To investigate the accuracy of biological markers compared to overnight PSG and to HSAT in people with different degrees of severity of OSA (mild, moderate, severe). To evaluate the accuracy of biomarkers from different sample types to identify OSA.

实验结论

提炼研究问题、关键发现与证据，快速把握文章的核心贡献。

研究问题: 确定血液、唾液、尿液或呼出气冷凝液中任何类型的生物标志物检测成人（>18岁）阻塞性睡眠呼吸暂停（OSA）的准确性，并比较其与整夜多导睡眠监测（PSG）和家庭睡眠呼吸暂停检测（HSAT）的准确性。
核心机制: 文中未明确说明
主要证据: 文中未明确说明
研究意义: 作者认为，发现准确的OSA诊断方法有可能通过促进早期诊断、更好的风险分层和更高效的管理来革新睡眠医学。