- 讲师介绍
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讲师介绍
甘波谊
Boyi Gan 教授
美国德克萨斯大学MD安德森癌症中心
张义磊
西安交通大学 教授
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视频介绍
课程大纲：
Our lab has a long-standing interest in understanding nutrient signaling and metabolic stress response in both normal and cancer cells. Our recent work has studied the regulatory mechanisms of ferroptosis, a non-apoptotic cell death induced by metabolic stress, and its role in cellular metabolism, tumor suppression, and cancer therapy. Our studies link the tumor suppressor BAP1 to metabolic stress response and ferroptosis regulation. In addition, we revealed a critical role of ferroptosis in radiotherapy-induced cell death and tumor suppression and suggest to combine radiotherapy and ferroptosis inducers in cancer treatment. Finally, we recently uncovered a DHODH-mediated ferroptosis defense mechanism in mitochondria and identified DHODH inhibitors as ferroptosis inducers in cancer therapy. Together, our findings suggest that ferroptosis is an important tumor suppression mechanism and provide a broad framework for further understanding and targeting ferroptosis in cancer therapy.
Our lab has a long-standing interest in understanding nutrient signaling and metabolic stress response in both normal and cancer cells. Our recent work has studied the regulatory mechanisms of ferroptosis, a non-apoptotic cell death induced by metabolic stress, and its role in cellular metabolism, tumor suppression, and cancer therapy. Our studies link the tumor suppressor BAP1 to metabolic stress response and ferroptosis regulation. In addition, we revealed a critical role of ferroptosis in radiotherapy-induced cell death and tumor suppression and suggest to combine radiotherapy and ferroptosis inducers in cancer treatment. Finally, we recently uncovered a DHODH-mediated ferroptosis defense mechanism in mitochondria and identified DHODH inhibitors as ferroptosis inducers in cancer therapy. Together, our findings suggest that ferroptosis is an important tumor suppression mechanism and provide a broad framework for further understanding and targeting ferroptosis in cancer therapy.
