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兔抗人Plasma Kallikrein 1B 多克隆抗体
- 参考价格： 询价
- 品 牌： novus
- 货 号： NBP1-71442
- 靶 点： Plasma Kallikrein 1B 查看全部Plasma Kallikrein 1B 抗体
- 适应物种： 人
- 应用范围： 免疫印迹,酶联免疫吸附
- 克 隆 性： Polyclonal
- 宿 主： Rabbit
产品概览
| 背景： | Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. |
| 免疫原： | The antiserum was produced against synthesized peptide derived from human KLKB1. The immunogen region is: Internal. |
| 产品保证说明： | All of our products are backed by our 100% guarantee to work for stated and predicted species and applications. |
| 产品别名： | EC 3.4.21PPKKininogeninEC 3.4.21.34plasma kallikrein light chainFletcher factorplasma kallikrein heavy chainPlasma prekallikreinKLK3plasma kallikreinkininogeninkallikrein B, plasma (Fletcher factor) 1 |
产品特性
| 纯度： | Immunogen affinity purified |
靶点信息
| uniprot： |
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| 基因： | KLKB1 |
| 基因标志： | KLKB1 |
| 基因相关产品： | KNG1,PLG,FACTOR XII,KININOGEN,KLK4,F12,KLK1,A4GALT,SERPINA4,SPINK6,ZAK,SERPINC1,F2,F11,ELANE,PSAT1,PROS1,PLAG1,NPEPPS,PLAU |
| uniprot： |
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应用与保存
| 免疫原： | The antiserum was produced against synthesized peptide derived from human KLKB1. The immunogen region is: Internal. |
| 防腐剂： | 0.02% Sodium Azide |
| 稀释浓度： |
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其他
| 保存条件： | Store at -20C. Avoid freeze-thaw cycles. |
| 浓度： | 1 mg/ml |
| 温馨提示： | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies areguaranteedfor 1 year from date of receipt. |
| 特异性： | KLKB1 (heavy chain,Cleaved-Arg390) Antibody detects endogenous levels of fragment of activated KLKB1 resulting from cleavage adjacent to Arg390. |
| 缓冲液： | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
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