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兔PINK1 多克隆抗体
- 参考价格： 询价
- 品 牌： novus
- 货 号： BC100-494
- 靶 点： PINK1 查看全部PINK1 抗体
- 适应物种： 人,小鼠
- 应用范围： 免疫印迹,免疫细胞化学/免疫荧光,免疫细胞化学,免疫沉淀,肽酶联免疫吸附检测
- 克 隆 性： Polyclonal
- 宿 主： Rabbit
产品概览
| 背景： | PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins, and is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). PINK1 is synthesized as a 63 kD protein which undergoes proteolyt processing to generate at least two cleaved forms (55 kD and 42 kD). PINK1 and its substrates have been found in the cytosol as well as in different sub-mitochondrial compartments, and according to the recent reports; PINK1 may be targeted to OMM (outer mitochondrial membrane) with its kinase domain facing the cytosol, providing a possible explanation for the observed physical interaction with the cytosolic E3 ubiquitin ligase Parkin. Defective PINK1 may cause alterations in processing, stability, localization and activity as well as binding to substrates/interaction-partners which ultimately leads to differential effects on mitochondrial function and morphology. Mutations in PINK1 are linked to autosomal recessive early onset Parkinson's disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of alpha-synuclein, as well as proteasome dysfunction. |
| 免疫原： | A synthetic peptide made to the human PINK1 protein sequence (between residues 175-250). [Swiss-Prot Q9BXM7] |
| 产品保证说明： | All of our products are backed by our 100% guarantee to work for stated and predicted species and applications. |
| 产品别名： | Parkinson disease (autosomal recessive) 6EC 2.7.11.1PARK6serine/threonine-protein kinase PINK1, mitochondrialPTEN-induced putative kinase protein 1protein kinase BRPKBRPKFLJ27236PTEN induced putative kinase 1 |
产品特性
| 纯度： | Immunogen affinity purified |
靶点信息
| uniprot： |
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| 基因： | PINK1 |
| 基因标志： | PINK1 |
| 基因相关产品： | PARK7,SNCA,PARKIN PROTEIN,LRRK2,PARK2,ATP13A2,HTRA2,UCHL1,PTEN,DNM1L,ZNF645,MUL1,TRIM50,UTRN,CRMP1,DAPK2,DENR,MAPT,GBA,MFN2 |
| 胞内定位： | Mitochondrial |
| entrez： |
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| uniprot： |
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应用与保存
| 免疫原： | A synthetic peptide made to the human PINK1 protein sequence (between residues 175-250). [Swiss-Prot Q9BXM7] |
| 防腐剂： | 0.1% Sodium Azide |
| 应用说明： | This PINK1 antibody can be used for Immunocytochemistry/Immunofluorescence, Peptide ELISA and Western blot, where specific bands are seen at 45, 55 and 67 kDa. In WB, this antibody has been used in CCCP treated HeLa whole cell lysate. Use in immunprecipitation reported in scientific literature (PMID 22078885) |
| 稀释浓度： |
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其他
| 对照肽： | PINK1 Peptide (BC100-494PEP) |
| 保存条件： | Store at 4C. Do not freeze. |
| 浓度： | 0.5 mg/ml |
| 温馨提示： | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies areguaranteedfor 1 year from date of receipt. |
| 缓冲液： | TBS with 0.1% BSA |
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