| 产品介绍： | Arachidonyl ethanolamide (AEA) is an endogenous lipid neurotransmitter with cannabinergic activity. It binds to both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of AEA. Metabolism of AEA by cyclooxygenase-2, leading to the formation of prostaglandin ethanolamides, and by lipoxygenases been documented as well. (±)5(6)-EET ethanolamide is a cytochrome P450 (CYP450) metabolite of AEA, although specific stereochemistry rather than a racemic mixture ensues from enzymatic metabolism, it is a potent and selective agonist of CB2 (Kι= 8.9 nM for CB2, 11.4 μM for CB1), effectively suppressing forskolin-stimulated accumulation of cAMP through this Gi-coupled receptor (IC50= 9.8 nM). |
