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抗人cyp21a2多克隆抗体
- 参考价格： ¥1100.0 - 2310.0
- 品 牌： abgent
- 货 号： AP7880c
- 适应物种： 人
- 应用范围： 免疫印迹,免疫组化,流式细胞技术,免疫荧光
- 克 隆 性： 多克隆
- 亚 型： Rabbit Ig
- 抗体类型： 一抗
产品概览
| 背景： | CYP21A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in CYP21A2 gene cause congenital adrenal hyperplasia.REFERENCESGuerra-Junior,G., Clin. Exp. Immunol. 155 (2), 182-188 (2009) Abid,F., Clin. Chem. Lab. Med. 46 (12), 1707-1713 (2008) Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004) |
| 其他名字： | CYP21A2; CYP21; CYP21B; Steroid 21-hydroxylase; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B |
靶点信息
| 基因id： | 1589 |
| 蛋白名： | CYP21A2 |
| 胞内定位： | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein |
| 同义词： | CYP21, CYP21B |
应用与保存
| 稀释浓度： | WB~~1:1000WB~~1:1000IHC~~1:50~100FC~~1:10~50IF~~1:10~50 |
| 注意事项： | CYP21A2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | Guerra-Junior,G., Clin. Exp. Immunol. 155 (2), 182-188 (2009) Abid,F., Clin. Chem. Lab. Med. 46 (12), 1707-1713 (2008) Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004) |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 主要序列号： | P08686 |
| 分子量： | 55887 Da |
| 功能： | Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. |
| 规格： | 80 µl (8 western blots) | 价格： | ¥1100.00 |
| 规格： | 400 µl (40 western blots) | 价格： | ¥2310.00 |
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