• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Severe Combined lmmunodeficient (SCID) Mice in Vaccine Assessment

        互联网

        595
        New or improved vaccines will require testing before they are licensed for use in the general population. Although toxicity and immunological data can be obtained from phase 1 human trials, in the vast majority of cases, it is not possible to challenge vaccine recipients with the specific infectious agent in order to assess protection. Therefore, prior to large-scale production of vaccines and their assessment in phase 2 and 3 clinical trials, there is a requirement for in vivo studies that can predict the efficacy of the vaccines. Although many animal models are available for infectious disease studies, they all rely on the animal’s own immune system for the generation of the protective responses, and these may not reflect the immunological responses generated in the human. In addition, some infections are specific to humans, and it is sometimes very difficult to find suitable animal species that human pathogens will infect. This may be because of the lack of appropriate receptors, the presence of a functional immune system able to eliminate the pathogen, and the fact that models cannot always be relied on to re-create the normal pathophysiology.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序