• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Solid-Phase Supports for Oligonucleotide Synthesis

        互联网

        663
        The solid-phase strategy for oligonucleotide synthesis has been responsible for much of the widespread utilization of synthetic oligonucleotides. Indeed, without this approach, the chemical synthesis of oligonucleotides would have remained a difficult and tedious task suitable for only the most dedicated chemist. Now of course, as anyone owning an automated synthesizer knows, the solid-phase synthesis of oligonucleotides is as easy as pressing a few buttons. However, despite the obvious advantages of solid-phase synthesis, the development of satisfactory procedures for oligonucleotide synthesis required almost 20 years from the first introduction of this technique. This was primarily because of two obstacles that had to be overcome. The first was the need for rapid and highly efficient coupling reactions, and the second was the need for a suitable solid-phase support. This chapter is devoted to a treatment of the solid-phase supports and the important covalent linkage that binds the oligonucleotide to it.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序