【求助】请教：myosin 2 和 nonmuscle myosin2有何区别
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请教各位老师，myosin 2 和 nonmuscle myosin2有何区别？有没有人做这个的，能否提供一些资料，谢谢。
自己顶一下，希望各位老师帮忙
Myosin II (also known as conventional myosin) is the best-studied example of these properties.
Myosin II contains two heavy chains, each about 2000 amino acids in length, which constitute the head and tail domains. Each of these heavy chains contains the N-terminal head domain, while the C-terminal tails take on a coiled-coil morphology, holding the two heavy chains together (imagine two snakes wrapped around each other, such as in a caduceus). Thus, myosin II has two heads.
It also contains 4 light chains (2 per head), which bind the heavy chains in the "neck" region between the head and tail. These light chains are often referred to as the essential light chain and the regulatory light chain.
In muscle cells, it is myosin II that is responsible for producing the contractile force. Here, the long coiled-coil tails of the individual myosin molecules join together, forming the thick filaments of the sarcomere. The force-producing head domains stick out from the side of the thick filament, ready to walk along the adjacent actin-based thin filaments in response to the proper chemical signals.
关于nonmuscle myosin 2，请查阅这篇文献Load-dependent mechanism of nonmuscle myosin 2
链接：http://www.pnas.org/content/104/24/9994.abstract
Myosin II contains two heavy chains, each about 2000 amino acids in length, which constitute the head and tail domains. Each of these heavy chains contains the N-terminal head domain, while the C-terminal tails take on a coiled-coil morphology, holding the two heavy chains together (imagine two snakes wrapped around each other, such as in a caduceus). Thus, myosin II has two heads.
It also contains 4 light chains (2 per head), which bind the heavy chains in the "neck" region between the head and tail. These light chains are often referred to as the essential light chain and the regulatory light chain.
In muscle cells, it is myosin II that is responsible for producing the contractile force. Here, the long coiled-coil tails of the individual myosin molecules join together, forming the thick filaments of the sarcomere. The force-producing head domains stick out from the side of the thick filament, ready to walk along the adjacent actin-based thin filaments in response to the proper chemical signals.
关于nonmuscle myosin 2，请查阅这篇文献Load-dependent mechanism of nonmuscle myosin 2
链接：http://www.pnas.org/content/104/24/9994.abstract
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