Acute Physiologic and Morphologic Assessment Following Subarachnoid Hemorrhage
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Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease, comprising 5% of all strokes and affecting 27,000
people in the USA annually. The acute changes in vascular physiology and morphology immediately following SAH are poorly understood,
and likely contribute to early fatality. Recent investigations have focused attention on early brain injury resulting from
acutely decreased cerebral blood flow and perfusion pressure mediated by increased intracranial pressure and vasoconstriction.
Subsequent destruction of the microvascular architecture augments global ischemia and initiates a cascade of cellular injury.
This chapter presents a review of recent literature addressing the acute changes observed following SAH. We have also provided
a brief overview of basic methodologies utilized in these investigations.
