• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Engineering of a 3D Nanostructured Scaffold Made of Functionalized Self-Assembling Peptides and Encapsulated Neural Stem Cells

        互联网

        536
        Three-dimensional (3D) in vitro models of cell culture aim to fill the gap between the standard 2D cell studies and the in vivo environment. Especially for neural tissue regeneration approaches where there is little regenerative capacity, such models must rely on scaffolds that mimic the extracellular matrix in providing support; allowing the natural flow of oxygen, nutrients, and growth factors; and possibly favoring neural cell regrowth. Their combined use with stem cells has many potentialities for tissue engineering applications. Here, we describe a new 3D model of stem cell culture, using a nanostructured biomaterial, made of self-assembling peptides, where adult neural stem cells are completely embedded. This new 3D cell culture system takes advantage of the nano- and microfiber assembling process of these biomaterials under physiological conditions. The assembled scaffold forms an intricate and biologically active matrix able to display specifically designed functional motifs such as RGD, BMHP1, and BMHP2. Such model has the potential to be tailored to develop ad hoc designed peptides for specific cell lines.
        ad image
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序