【进展|热点】Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiol
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Immunity. 2009 Nov 20;31(5):711-21.
Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.
Ransohoff RM.
Neuroinflammation Research Center (Lerner Research Institute) and Mellen Center for MS Treatment and Research (Neurological Institute), Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA. ransohr@ccf.org
There are several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobiology. This review limns several illustrative examples and presents general principles of chemokine action that are manifest in both systems. These include the following: (1) chemokines tend equally to arrest cells and to make them move, in the process of positioning target cells with spatiotemporal precision; (2) signaling and nonsignaling receptors collaborate to adjust the chemokine environment for maximal efficacy; and (3) expression of a single chemokine receptor on circulating blood cells and parenchymal cells is often used to coordinate complex tissue responses. The challenge is to integrate knowledge of the roles of key receptors (as well as their ligands) into a coherent account of events during pathologic processes, in order to guide therapeutic development.
Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.
Ransohoff RM.
Neuroinflammation Research Center (Lerner Research Institute) and Mellen Center for MS Treatment and Research (Neurological Institute), Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA. ransohr@ccf.org
There are several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobiology. This review limns several illustrative examples and presents general principles of chemokine action that are manifest in both systems. These include the following: (1) chemokines tend equally to arrest cells and to make them move, in the process of positioning target cells with spatiotemporal precision; (2) signaling and nonsignaling receptors collaborate to adjust the chemokine environment for maximal efficacy; and (3) expression of a single chemokine receptor on circulating blood cells and parenchymal cells is often used to coordinate complex tissue responses. The challenge is to integrate knowledge of the roles of key receptors (as well as their ligands) into a coherent account of events during pathologic processes, in order to guide therapeutic development.
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Pumbemd文献浩如烟海。不知道楼主贴上此文，意欲告诉我们什么？这么文章提出了什么新观点？有什么值得我们学习？
非常感谢您的发帖。对于【进展】类帖子的发帖，请参考此帖：
http://www.dxy.cn/bbs/post/view?bid=163&id=14667420&sty=1&tpg=1&age=-1
谢谢！
