The senescence-accelerated mouse (SAM) strains, consisting of nine SAM-prone (SAMP) mice strains and three SAM-resistant (SAMR) strains, have been used extensively as models for various age-related disorders. SAMP mice undergo accelerated aging while SAMR mice undergo normal agi ...
No animal spontaneously suffers from Alzheimer’s disease (AD), nor can it be experimentally induced. However, there is a huge research need for models of AD. Lesion-induced vertebrate models of this disease have been, and indeed remain, extremely important in the study of AD pathogenesis and p ...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and the presence of neuropathological hallmarks, including the accumulation of extracellular Aβ. Aspects of AD can be modeled in rodents by direct intracerebr ...
The PDAPP mouse has been a very useful model for studying mechanisms underlying amyloid-β (Aβ) metabolism, aggregation, and deposition, and for aiding in the development of new diagnostic and therapeutic approaches for Alzheimer’s disease (AD). One of the initial difficulties in produc ...
The search for a good animal, preferably mouse, model of Alzheimer’s disease (AD) is one of the most imperative in present medical research, given the increasing prevalence of this disorder in an aging population and its enormous social, economic, and personal impact. In 1996, Karen Hsiao and coll ...
Animal models are considered essential in research for elucidation of human disease processes and subsequent testing of potential therapeutic strategies. This is especially true for neurodegenerative disorders, in which the first steps in pathogenesis are often not accessible ...
Since the identification of the mutations in presenilin 1 and presenilin 2 genes more than a decade ago, a great deal of research has filled the gap in our knowledge of mutations underlying various phenotypes of Alzheimer’s disease (AD) that appear relatively early in the life of presenilin (PS) mut ...
One of the major challenges in biology is to understand better the molecular regulation of signaling pathways that control complex cellular processes such as motility and proliferation. The experimental approaches employed in such investigations must gather information on cha ...
Small photochromic molecules are widespread in nature and serve as switches for a plethora of light-controlled processes. In a typical photoreceptor, the different geometries and polarities of the photochrome isomers are tightly coupled to functionally relevant conformatio ...
In a truly interdisciplinary fashion, organic chemists and molecular biologists have engineered novel systems that allow externally applied light to regulate protein confirmation in living systems. These highly engineered systems typically involve two distinct parts. The f ...
Ligand-activated proteins can be controlled with light by means of synthetic photoisomerizable tethered ligands (PTLs). The application of PTLs to ligand-gated ion channels, including the nicotinic acetylcholine receptor and ionotropic glutamate receptors, is reviewed wi ...
Disrupted-in-Schizophrenia 1 (DISC1) is a strong candidate gene for schizophrenia and major mental disorders. After its discovery in the Scottish chromosomal translocation, DISC1 has gained considerable attention in neuropsychiatric research. Recent studies have implic ...
Accumulating evidence indicates that the genetic architecture of psychiatric disorders does not strictly conform to the common disease/common allele hypothesis. The contribution of common genetic variants, while likely, may be fundamentally different from those of rare gene ...
Evidence of altered antioxidant systems and signs of elevated oxidative stress are reported in peripheral tissue and brain of schizophrenic patients, including low levels of glutathione (GSH), a major thiol antioxidant and redox buffer. Functional and genetic data indicate that an im ...
Evidence obtained from schizophrenia post-mortem brain studies have pointed to deficiencies in inhibitory systems, in particular of the fast-spiking parvalbumin (PV)-positive inhibitory interneurons, as responsible for several aspects of schizophrenia pathophysio ...
It is now widely acknowledged that exposure to adverse environmental factors in utero may not only affect how the brain develops but have long-lasting consequences for later brain function in the adult offspring. This idea has gained particular prominence amongst researchers interes ...
Hypoxia has been discussed as a possible factor of obstetric complications in the pathophysiology of schizophrenia. This study investigated the effects of chronic neonatal hypoxia in rats as an animal model of schizophrenia. Methods: (1) After chronic neonatal hypoxia between postn ...
An increasing number of epidemiologic studies have implicated in utero exposure to infection in the etiopathogenesis of schizophrenia. Recent work has capitalized on the use of prospectively acquired data on infection based on maternal biomarkers. These studies suggest that seve ...
This chapter provides an overview on exposure to methylazoxymethanol (MAM) at embryonic day 17 as a promising animal model for schizophrenia that mimics behavioral abnormalities and deficits in prefrontal cortex networks. This early insult produces in adult offspring from E17 MAM- ...
The neonatal ventral hippocampal lesion (NVHL) rat model of schizophrenia has demonstrated broad heuristic utility as an investigative platform encompassing many of the behavioral, neurobiological, and developmental aspects of this devastating neuropsychiatric illn ...
关于丁香通
公司信息
个人用户
企业机构
