生物信息学技术

Abstract Table of Contents Figures Literature Cited Abstract This unit provides an overview of the major types of mutant alleles that can be generated by gene targeting in ES cells. It presents the growing public resources of premade gene

Abstract Table of Contents Materials Figures Literature Cited Abstract The locomotor activity of laboratory mice is a global behavioral trait which can be valuable for the primary phenotyping of genetical

Abstract Table of Contents Materials Figures Literature Cited Abstract The genetic manipulation of rodents through the generation of fully transgenic animals or via the modification of selective cells or

Abstract Table of Contents Literature Cited Abstract Mice count morally because they can be harmed. This raises a moral issue in animal experimentation. Three main ethical attitudes towards animals are reviewed here. The Kantian view denies moral value to animals because th

Abstract Table of Contents Materials Figures Literature Cited Abstract Maximal exercise performance is a multifactorial process in which the cardiovascular component, the innervation of the musculature, a

Abstract Table of Contents Materials Figures Literature Cited Abstract The majority of current cardiovascular research involves studies in genetically engineered mouse models. The measurement of heart rat

Abstract Table of Contents Materials Figures Literature Cited Abstract The use of mice for the evaluation and study of cardiovascular pathophysiology is growing rapidly, primarily due to the relative ease

Abstract Table of Contents Materials Figures Videos Literature Cited Abstract The possibility of imaging tumors in live mice has opened new opportunities for cancer resear

Abstract Table of Contents Figures Literature Cited Abstract Murine models have been utilized with increasing frequency mainly due to availability of genetically engineered models. With advancement in high spatial and temporal resolution,

Abstract Table of Contents Materials Figures Literature Cited Abstract The generation of ligand?activated site?specific Cre recombinases has led to the development of cell type?specific temporally control

Abstract Table of Contents Materials Figures Literature Cited Abstract A procedure for post?mortem examination (or necropsy) of mice is provided. The aim is to obtain a ?holistic? picture of organs and sy

Abstract Table of Contents Figures Literature Cited Abstract Conditional gene manipulations in mice are increasingly popular strategies in biomedical research. These approaches rely on the production of conditional genetically engineered m

Abstract Table of Contents Materials Figures Literature Cited Abstract Measurements of auditory evoked potentials can be used to determine reliably an audiometric representation of hearing sensitivity in

Abstract Table of Contents Figures Literature Cited Abstract Experimental mouse models are widely used for preclinical research on dyslipidemia, atherosclerosis, and cardiometabolic diseases. This unit reports the most commonly used bioche

Abstract Table of Contents Materials Figures Literature Cited Abstract Mouse models that mimic human diseases are invaluable tools to study and discover genetic and pharmacological therapies for human dis

Abstract Table of Contents Materials Figures Literature Cited Abstract Autism is diagnosed by three major symptom categories: unusual reciprocal social interactions, impaired communication, and repetitive

Abstract Table of Contents Materials Figures Literature Cited Abstract The neural crest is a unique structure in vertebrates. Neural crest cells play important roles in the formation of organs that charac

Abstract Table of Contents Materials Figures Literature Cited Abstract The use of BAC/P1 as a vector for the generation of a transgene has gained popularity after the genomic annotation of many organisms

Abstract Table of Contents Materials Figures Literature Cited Abstract In most organisms, physiological variables are regulated by an internal clock. This endogenous circadian (?24?hr) clock enables organ

Abstract Table of Contents Materials Figures Literature Cited Abstract Pain afflicts a fifth of the population, and animal models have proven useful in target validation and analgesic drug development. Th