proTAME,1362911-19-0

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proTAME

CAS No. : 1362911-19-0

MCE 国际站：proTAME

产品活性：proTAME 是 TAME 的一种细胞渗透性前体形式，是一种后期促进复合物/环体 (APC/C) 抑制剂。proTAME 导致细胞周期停滞在中期。

研究领域：Cell Cycle/DNA Damage

作用靶点：APC

In Vitro: ProTAME prevents anaphase entry in mouse and bovine oocytes and also in mouse 2-cell embryos. proTAME (0-100 μM ) treatment shows dose-dependent metaphase arrest in mammalian oocytes and early cleavage embryos. And the metaphase arrest induced by this drug does not require spindle assembly checkpoint (SAC) activity.
ProTAME arrest of meiosis I in mouse oocytes is due to the inhibition of APC/C. In contrast to the somatic cells, the arrest in oocytes and embryos is not reversible.
proTAME (0-20 μM) dose-dependently affects morphological parameters of the spindle in oocytes and in embryos.
proTAME is efficient in overcoming resistance caused by the hyperphosphorylation of CDH1 in glioblastoma cells, polo-like kinase 1 (PLK1)-based drug resistance in ovarian cancer cells and CDC20-based resistance in diffuse large B-cell lymphoma.
proTAME inhibits OVCAR-3 cells growth with an IC₅₀ of 12.5 μM.

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