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- 2025年12月05日
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- 文献和实验
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- 保存条件：
4°C, protect from light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1675201-90-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1196.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥3000.0 |
| 规格： | 50 mg | 产品价格： | ￥4600.0 |
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BMS-8
CAS No. : 1675201-90-7
MCE 国际站：BMS-8
产品活性：BMS-8 抑制 PD-1/PD-L1 相互作用，其 IC50 值为 7.2 μM。BMS-8 直接与 PD-L1 结合，可诱导 PD-L1 同源二聚体的形成，从而阻止其与 PD-1 的相互作用。
作用靶点：PD-1/PD-L1
In Vitro: BMS-8 tends to have a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124.
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文献和实验Immunostaining of Cells Adherent to Coverslips
, or in 6 well plates. Coat overnight (4°C) with 3 ml/dish or well of 40 µg/ml BMS made up in ddH2O. 2) Remove coating solution and block with 1% BSA for 4 hr at 4°C. 3) Isolate cells and plate at 6 x 105 cells/ml (3 ml/well). Allow cells to adhere for 1 hr
Lacrimal Experimental Protocol (4/4/94)
Lacrimal Experimental Protocol (4/4/94) Day Before: 1. Prepare (6) 50 ml conicals each containing 50 ml of DMEM (high glucose) and gentamycin (50 µg/ml); place in incubator (90% O2, 10% CO2). 2. Thaw FBS (place at 4°C).
Immunostaining of Cells Adherent to Coverslips
. Coat overnight (4°C) with 3 ml/dish or well of 40 µg/ml BMS made up in ddH2O. 2) Remove coating solution and block with 1 BSA for 4 hr at 4°C. 3) Isolate cells and plate at 6 x 105
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