Camrelizumab

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Camrelizumab

CAS No. : 1798286-48-2

MCE 国际站：Camrelizumab

产品活性：Camrelizumab (SHR-1210) 是一种人源化的 IgG4-κ 抗 PD-1 单克隆抗体 (mAb)。Camrelizumab 以 3 nM 的高亲和力与 PD-1 结合，抑制 PD-1 和 PD-L1 的结合作用的 IC₅₀ 值为 0.70 nM。Camrelizumab 是一种有效的抗 PD-1/PD-L1 活性分子，可用于癌症研究，包括非小细胞肺癌、食管鳞状细胞癌、霍奇金淋巴瘤和晚期肝癌等。

研究领域：Immunology/Inflammation

作用靶点：PD-1/PD-L1

In Vitro: In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC₅₀ of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC₅₀ of 0.38 nM.

In Vivo: Camrelizumab (3 mg/kg) combines with apatinib (200 and 100 mg/kg) inhibits the tumor inhibition rates reached 63.1% and 87.3%, respectively in human PD-1 transgenic mice.

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