- ￥1520 - 4650
- MedChemExpress(MCE)
- 美国
- HY-134884
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
PD-1/PD-L1-IN-8
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2230911-59-6
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥1520.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥3200.0 |
| 规格： | 10 mg | 产品价格： | ￥4650.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
INCB086550
CAS No. : 2230911-59-6
MCE 国际站：INCB086550
产品活性：INCB086550 是一种强效的口服小分子 PD-L1 抑制剂，其对人、食蟹猴和大鼠的 PD-L1 IC50 值分别为 3.1, 4.9 和 1.9 nM。INCB086550 促进细胞表面 PD-L1 二聚化，并诱导 PD-L1 进入高尔基囊泡，随后转运到细胞核。INCB086550 可用于多种癌症疾病的研究。
作用靶点：PD-1/PD-L1
In Vitro: INCB086550 (0.1-10000 nM, 20 h) has no overt toxicity to pleural effusion fluids cells.
INCB086550 (1 µmol/L, 24 h) induces the dimerization of cell-surface PD-L1 and resulting in internalization.
In Vivo: INCB086550 (15, 200 mg/kg for Oral gavage, once or twice) inhibits greater than 90% of unoccupied cell surface PD-L1 in MDA-MB-231 mice model.
INCB086550 (2, 20, or 200 mg/kg for Oral gavage, b.i.d) inhibits tumor growth in MC38 huPD-L1 mice model.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Protein-protein Interaction Inhibitor Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Atezolizumab | Pembrolizumab | Cilengitide | BMS-1 | Nivolumab | BMS-202 | JQ-1 (carboxylic acid) | Durvalumab | Tomivosertib | Avelumab | Anti-Mouse PD-L1 Antibody (10F.9G2) | Anti-Mouse PD-1 Antibody (RMP1-14) | Pembrolizumab (anti-PD-1) | Sulindac | CA-170 | BMS-1166 | Camrelizumab | Fraxinellone | Tislelizumab | PD-1/PD-L1-IN-9 | BMS-8 | Sintilimab | PD-L1-IN-1 | Evixapodlin | PROTAC PD-1/PD-L1 degrader-1 | Toripalimab | Onvatilimab | PD-1-IN-17
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
