TRPV3 antagonist 74a,1432051-6

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TRPV3 antagonist 74a

CAS No. : 1432051-63-2

MCE 国际站：TRPV3 antagonist 74a

产品活性：TRPV3 antagonist 74a 是一种有效的选择性 TRPV3 拮抗剂。TRPV3 antagonist 74a 对其他离子通道面板显示无显著活性。TRPV3 antagonist 74a 可用于神经性疼痛的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca²⁺ responses.

In Vivo: TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly.
.TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold.

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