Faropenem

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Faropenem

CAS No. : 106560-14-9

MCE 国际站：Faropenem

产品活性：Faropenem 是一种有效的口服-内酰胺抗生素 (beta-lactam antibiotic)。Faropenem 对许多革兰氏阳性和阴性需氧菌和厌氧菌具有广谱体外抗菌活性。 Faropenem 对几乎所有的 β-内酰胺酶都具有抗性，包括广谱 β-内酰胺酶和 AmpC-内酰胺酶。 Faropenem 是法罗培南美多索米的口服前体，常用于呼吸道感染的研究。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Bacterial

In Vitro: Faropenem is not active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, Pseudomonas aeruginosa or Stenotrophomonas maltophilia.
Faropenem is against all isolates of B. anthracis. The MIC values ranged from ≤0.06 to >64 μg/liter, and the MIC₉₀ value is 0.5 μg/ml. The MIC₉₀ value for Faropenem is lower than that observed for other β-lactams, such as Meropenem, Amoxicillin-clavulanate, and Penicillin, for which the MIC₉₀ values are 4 μg/ml, 4 μg/ml, and 8 μg/ml, respectively.

In Vivo: Faropenem ( i.p. at 24 h postchallenge at 4-, 6-, and 12-h intervals; 10, 20, 40, and 80 mg/kg/day; 14 days) demonstrates a high level of activity against B. anthracis in the murine post-exposure prophylaxis inhalation model.

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