Grepafloxacin,119914-60-2

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Grepafloxacin

CAS No. : 119914-60-2

MCE 国际站：Grepafloxacin

产品活性：Grepafloxacin (OPC-17116) 是一种口服活性氟喹诺酮类抗生素 (antibiotic)，对包括肺炎链球菌在内的社区获得性呼吸道病原体具有有效活性。Grepafloxacin 具有较高的组织渗透性和良好的药效学特性。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Bacterial

In Vitro: Grepafloxacin (OPC-17116; 0-1 mg/L; 14-21 d) has antibiotic activity with a MIC value of ≤ 0.006 mg/L for E. coli strain.
Grepafloxacin (0-1 mg/L; 3 h) has antimicrobial activity against mycobacteria in macrophages with a MIC value of 0.5 mg/L for M. avium.
Grepafloxacin exhibits potent in vitro antibacterial activity against Gram-positive bacteria such as Streptococcus pneumoniae and high in vivo efficacy on the experimental systemic infections caused by the Gram-positive and -negative bacteria tested.

In Vivo: Grepafloxacin (OPC-17116; 200 mg/kg; p.o.; Balb/c mice) displays good safety profile in terms of phototoxicity.
Grepafloxacin (25-200 mg/kg; p.o.; 5 days/week for 4 weeks; female C57BL6/J-Lyst bg-J/ mice/beige mice) has modest activities in both intranasal (IN) infection and intravenous (IV) Mycobacterium avium infection models.

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