Thioperamide硫丙咪胺马来酸,148440-81-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Thioperamide maleate

CAS No. : 148440-81-7

MCE 国际站：Thioperamide maleate

产品活性：Thioperamide maleate (MR-12842 maleate) 是一种有效的，具有口服活性的，可透过血脑屏障的选择性 H3 受体拮抗剂，抑制 [³H] 组胺释放的K_i 为 4.3 nM。Thioperamide maleate 抑制 [³H] 组胺合成的 K_i 为 31 nM 。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Thioperamide inhibits [³H]-(R)α-MeHA binding rat brain and guinea-pig lung with K_is of 2.1 nM and 2.0 nM, respectively. Thioperamide competitively blocks H3-autoreceptors regulating [³H]histamine release with a mean apparent K_i of 4 nM.
Thioperamide (0.01-100 μM; 24 hours) promotes the viability of NE-4C stem cells in a concentration-dependent manner.
Thioperamide displays similar potencies at human H4 and H3 receptors (K_i=43 and 60 nM, respectively).

In Vivo: Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice.

相关产品：Histamine  |  Clemastine fumarate  |  Terfenadine  |  Amitriptyline hydrochloride  |  Astemizole  |  Cimetidine  |  Loratadine  |  Osthole  |  Mecamylamine hydrochloride  |  Diphenhydramine hydrochloride  |  Desloratadine  |  Doxepin Hydrochloride  |  Perphenazine  |  Ritanserin  |  Promethazine hydrochloride  |  Famotidine  |  Fexofenadine hydrochloride  |  Mianserin hydrochloride  |  (S)-(+)-Dimethindene maleate  |  Cetirizine dihydrochloride  |  Chlorpheniramine maleate  |  Ketotifen fumarate  |  Mepyramine maleate  |  Ranitidine hydrochloride  |  Benztropine mesylate  |  JNJ-7777120  |  Meclizine dihydrochloride  |  Lodoxamide  |  Mirtazapine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds