ML-193,713121-80-3

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ML-193

CAS No. : 713121-80-3

MCE 国际站：ML-193

产品活性：ML-193 (CID 1261822) 是一种有效和选择性的 GPR55 拮抗剂，IC₅₀ 值为 221 nM。ML-193 对 GPR55 的选择性是 GPR35，CB1 和 CB2 的 27 倍以上。ML-193 可以改善帕金森氏病 (PD) 大鼠的运动和感觉运动缺陷。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：GPR55

In Vitro: ML-193 (0.01-100 μM; pretreated for 15 min) inhibits β-arrestin trafficking induced by L-α-lysophophosphatidylinositol (LPI, 10 μM) and ML186 (1 μM) with IC₅₀s of 0.22 μM and 0.12 μM, respectively.
ML-193 (0.01-10 μM; pretreated for 30 min) decreases the LPI-mediated ERK1/2 phosphorylation, with an IC₅₀ of 0.2 μM in U2OS cells.
ML-193 (5 μM; pretreated for 30 min) attenuates the GPR55 agonists induced increases in hNSCs proliferation rates.
ML-193 (5 μM; 10 d) attenuates the ML184-induced increases in hNSCs differentiation.

In Vivo: ML193 (1 and 5 µg/rat; intra-striatal at a rate of 1 μL/min) attenuates sensorimotor deficits and slip steps, increases motor coordination in PD rats.

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