BMS-986242,1923844-48-7

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BMS-986242

CAS No. : 1923844-48-7

MCE 国际站：BMS-986242

产品活性：BMS-986242 是一种具有口服活性、强效和选择性的 indoleamine-2,3-dioxygenase 1 (IDO1) 抑制剂。BMS-986242 可用于癌症研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Indoleamine 2,3-Dioxygenase (IDO)

In Vitro: BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC₅₀>25 μM for all targets except nAChR a1 (IC₅₀=12.3 μM) and nAChR a7 (IC₅₀>6 μM with ∼20 % max inhibition).

In Vivo: BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses.

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