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- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥945.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1450.0 |
| 规格： | 25 mg | 产品价格： | ￥2900.0 |
| 规格： | 50 mg | 产品价格： | ￥3950.0 |
| 规格： | 100 mg | 产品价格： | ￥5530.0 |
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ML162
CAS No. : 1035072-16-2
MCE 国际站：ML162
产品活性：ML162 是一种共价谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂。ML162 对表达突变 RAS 癌基因的细胞系具有选择性的致死作用。
研究领域：Metabolic Enzyme/Protease | Apoptosis
作用靶点：Glutathione Peroxidase | Ferroptosis
In Vitro: ML162 (compound 1a) shows nanomolar potencies against two HRASG12V expressing cell lines, with IC50 values of 25 nM and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively.
ML162 (8 μM; 24 hours) treatment increases the expression of p62 and Nrf2 in chemoresistant HN3R and HN3-rslR cells, inactivates Keap1, and increases expression of the phospho-PERK-ATF4-SESN2 pathway.
ML162 induces the head and neck cancer (HNC) cell death to varying degrees, with parental HN3 cells more sensitive and cisplatin-resistant (HN3R) and acquired RSL3-resistant (HN3-rslR) cells less sensitive.
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