NAZ2329,2809469-05-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

NAZ2329

CAS No. : 2809469-05-2

MCE 国际站：NAZ2329

产品活性：NAZ2329 是受体型蛋白质酪氨酸磷酸酶 (RPTPs) R5 亚家族的第一个细胞可渗透抑制剂，相对于其他 PTPs，它变构且优先抑制PTPRZ (hPTPRZ1 的 IC₅₀ = 7.5 µM) 和 PTPRG (hPTPRG IC₅₀ = 4.8 µM)。NAZ2329 与 PTPRZ 的 D1结构域结合，相对于 PTPRZ 整个 (D1 + D2) 片段，其更有效地抑制 PTPRZ1-D1片段，其 IC₅₀ 为1.1 µM。NAZ2329 可有效抑制胶质母细胞瘤细胞的肿瘤生长并抑制干细胞样特性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: NAZ2329 (0-25 μM; 48 hours) dose-dependently inhibits cell proliferation and migration in all cell lines (rat glioblastoma cells bearing C6 clone and human U251 glioblastoma cells) .
?NAZ2329 (25 μM; 0-90 min) obviously promotes the phosphorylation level of paxillin at Tyr-118 site, leading to inhibition for PTPR substrate.

In Vivo: NAZ2329 (22.5 mg/kg; intraperitoneal injection; twice per week; 40 days) alone? has a moderate inhibitory effect. However, the combination of Temozolomide and NAZ2329 exerts a significantly increased inhibition of tumor growth compared with the control group, the NAZ2329 monotherapy group and the Temozolomide monotherapy group.

相关产品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Phosphatase Inhibitor Library  |  Heterocyclic Compound Library  |  Cyclosporin A  |  Tacrolimus  |  SHP099  |  Calyculin A  |  β-Glycerophosphate disodium salt pentahydrate  |  Salubrinal  |  Okadaic acid  |  Ebselen  |  Batoprotafib  |  L-Ascorbic acid 2-phosphate trisodium  |  Sodium orthovanadate  |  Suramin sodium salt  |  RMC-4550  |  TPI-1  |  Vociprotafib  |  Osunprotafib  |  DT-061  |  GSK 2830371  |  Sodium metatungstate  |  Idoxuridine  |  SF1670  |  NSC 663284  |  MSI-1436 lactate  |  BCI  |  D-erythro-Sphingosine  |  NSC-87877  |  Razuprotafib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds