AKB-6899,1007377-55-0

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AKB-6899

CAS No. : 1007377-55-0

MCE 国际站：AKB-6899

产品活性：AKB-6899 是一种脯氨酰羟化酶域 3 (PHD3) 抑制剂，是一种选择性 HIF-2α 稳定剂。AKB-6899 还增加了 GM-CSF 处理的巨噬细胞产生的 sVEGFR-1，并具有抗肿瘤和抗血管生成作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：HIF/HIF Prolyl-Hydroxylase

In Vitro: AKB-6899 (10 μM; 24 hours) increases the leves of HIF-2α protein, with no corresponding increase in HIF-1α. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, with no effect on HIF-1α accumulation or VEGF production.

In Vivo: AKB-6899 (17.5 mg/kg; i.p.; 3 times per week; for 16 days) treatment significantly reduces tumor growth in a murine melanoma model.

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